Microfluidic cell biology

This page is a comprehensive resource on microfluidic technologies to study cellular processes and functions. Here you can access our expertise pages, reviews to learn more about the advantages, challenges, applications, and latest developments of microfluidic cell biology.

Micropipette aspiration of cells and tissues

Micropipette aspiration is a powerful non-invasive technique to evaluate how biomechanical properties of single cells or tissue govern cell shape, cell response to mechanic stimuli, transition from nontumorigenic to tumorigenic state or morphogenesis

Microfluidic cell biology

Mimicking in-vivo environments: biochemical and biomechanical stimulation

Cells are constantly exposed to biochemical stimulation from the early embryonic stage to adult life. The spatiotemporal regulation of these signals is essential as it determines cell fate, phenotype, metabolic activity as well as pathological behaviors. The fast response and high stability of Fluigent instruments make them the best solution available on the market to reproduce these complex variations in vitro.

Microfluidic cell biology

Passive and active mechanical stimulation in microfluidic systems

Indirect mechanical forces and shear stress are integral parts of the cellular microenvironment. Reproducing these mechanical forces and shear stress is critical to capture the physiology of living tissues. Three types of flows are typically generated for producing shear stress : laminar, pulsatile, or interstitial flow.

Prostate organoid culture under fluorescent microscope

Microfluidic cell biology

Prostate Organoid Culture in Microbeads

Microbead-based microfluidics is a powerful technique for the generation of organoid cultures in 3D matrices to mimic the complex in-vivo environment that supports cell physiological and pathological behaviors.

Microfluidic cell biology

Why is a controlled shear-stress a key parameter of your microfluidic experiments?

Mechanical forces are potent regulators of cellular structures and functions in both health and disease. Of these forces, shear stress is particularly important as it stimulates the release of vasoactive substances and changes gene expression, cell metabolism, and cell morphology.